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Nuclear-cytoplasmic translocation of the transporter regulator RS1. Mechanism and control

Автор:  Alina F.
мягкая обложка
112 страниц
2009 год
Издательство:  Книга по Требованию
Цена:
2359 руб
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Описание:After confluence, phosphorylation of serine 370 of pRS1 by PKC takes place leading to enhancement of RS1 nuclear export and predominantly cytoplasmic distribution of the protein. According to the proposed model, in subconfluent cells, RS1 is actively imported into the nucleus whereas nuclear export of RS1 is not active. Thus, RS1 might play a role in the regulation of the solute carriers during specific phases of the cell cycle. Nuclear location of RS1 was found to be regulated by the cell cycle. The RS1 protein participates in regulation of Na+-D-glucose cotransporter SGLT1 and other solute carriers. The adjacent protein kinase C (PKC) phosphorylation site was shown to control nuclear localization driven by NS during confluence. A nuclear shuttling signal (NS) in pRS1 was identified that mediates translocation of RS1 into and out of the nucleus via importin ss1 and CRM1, respectively. Gene expression profiling of mouse embryonic fibroblasts with RS1-/- genotype suggests that transcriptional regulation by RS1 might be important for the cell cycle and cell division. In the present study, the mechanism and regulation of confluence-dependent nuclear location of RS1 was investigated.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Thanks For The Memories

Edgar must not have known that Bob Hope was connected to Kissinger. So, the information gathered that evening — not only Hoover and his friends' direct answers to questions, but their attitudes, and sexual preferences, etc. - were all recorded directly into my mind files. From then on the Council had "Hoover by the balls or was it the pussy?" my controllers joked. From then on the FBI was under Council control and they even got Hoover to put blocks and different rules, regulations, and codes directly into the FBI operations. That began to set up a controlling mechanism for the future so that when the next FBI director took office, things inside the Bureau would be in place so the Council could continue to manipulate them toward their Ultimate year 2000 goal. Alan Cranston Senator Alan Cranston was Bob's right-hand political man in California. He also attended Bob's parties. Alan carried out things Bob wanted done in the government sector. Bob's business dealings ran deep into world governments. He used government agencies as a tool for his benefit and he «bought» people already working in the government so that he could control them and "get things in order," he would say ...»

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