DNA Content Analysis and Invitro Cytotoxicity in Bladder Cancer Patients. Flow Cytometric Evaluation of DNA Content Analysis and Therapeutic Responses (Invitro Cytotoxicity) of Transitional Cell Carcinoma Patients

This gets shorter with age. In a baby it is about twenty thousand letters long, while in a sixty year-old it is less than half that length. Cells from tumours have lost even more DNA from the chromosome ends. About forty letters are dropped from this section of the message each time a cell divides, so that an old body works from an imperfect instruction manual, full of typographic errors. The same happens to mitochondria! genes, which are shot full of holes as rhe years conrinue their inexorable progress. Old age is itself in part the result of genetic accidents. Human cells in culture age more quickly when they carry a defect which increases the mutation rate and some children who inherit a tendency towards cancer also show symptoms of senility much earlier than normal. The immune system, which has the highest mutation rate of any part of the body, often fails as the years pass by. It seems that the decay of our elderly selves is, to some degree, a consequence of mutation. The influence of old age in damaging sperm and egg adds a certain irony to the claims of one institution devoted to the reversal of the decay of the human race, the Centre for Germinal Choice in California, in which Nobel Prize-winners make genetic deposits for hopeful mothers ...»